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Mushrooms are everywhere right now–in your coffee, your supplements, your wellness stack. But how many of us actually know what we’re talking about and why? In this episode, we’re breaking down the science behind functional mushrooms, from the bioactive compounds that make them interesting to the specific varieties showing up in supplements today.
We’re looking at what the research actually supports, where the evidence is solid, and where we’re still waiting on more data so you can decide for yourself whether mushrooms deserve a place in your routine.
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References
Łysakowska P, Sobota A, Wirkijowska A. Medicinal mushrooms: their bioactive components, nutritional value and application in functional food production—a review. Molecules. 2023;28(14):5393.
https://doi.org/10.3390/molecules28145393
Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal mushrooms: bioactive compounds, use, and clinical trials. International Journal of Molecular Sciences. 2021;22(2):634.
https://doi.org/10.3390/ijms22020634
Kumar K, Mehra R, Guiné RPF, et al. Edible mushrooms: a comprehensive review on bioactive compounds with health benefits and processing aspects. Foods. 2021;10(12):2996.
https://doi.org/10.3390/foods10122996
Singh A, Saini RK, Kumar A, Chawla P, Kaushik R. Mushrooms as nutritional powerhouses: a review of their bioactive compounds, health benefits, and value-added products. Foods. 2025;14(5):741.
https://doi.org/10.3390/foods14050741
Hassan M, Shahzadi S, Ransom RF, Kloczkowski A. Nature’s own pharmacy: mushroom-based chemical scaffolds and their therapeutic implications. Int J Mol Sci. 2023;24(5):4378.
https://doi.org/10.3390/ijms24054378
Freeman AM, Morris PB, Aspry K, et al. A clinician’s guide for trending cardiovascular nutrition controversies: part II. Journal of the American College of Cardiology. 2018;72(5):553–568.
https://doi.org/10.1016/j.jacc.2018.05.030
Panda SK, Luyten W. Medicinal mushrooms: clinical perspective and challenges. Drug Discovery Today. 2022;27(3):636–651.
https://doi.org/10.1016/j.drudis.2021.11.012
Phillips JM, Ooi SL, Pak SC. Health-promoting properties of medicinal mushrooms and their bioactive compounds for the COVID-19 era. Molecules. 2022;27(3):744.
https://doi.org/10.3390/molecules27030744
Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: improving human health and promoting quality life. International Journal of Microbiology. 2015;2015:376387.
https://doi.org/10.1155/2015/376387
Blumfield M, Abbott K, Duve E, et al. Examining the health effects and bioactive components in Agaricus bisporus mushrooms: a scoping review. Journal of Nutritional Biochemistry. 2020;84:108453.
https://doi.org/10.1016/j.jnutbio.2020.108453
Roupas P, Keogh J, Noakes M, et al. The role of edible mushrooms in health: evaluation of the evidence. Journal of Functional Foods. 2012;4(4):687–709.
https://doi.org/10.1016/j.jff.2012.05.003
Dai X, Stanilka JM, Rowe CA, et al. Consuming Lentinula edodes mushrooms daily improves human immunity. Journal of the American College of Nutrition. 2015;34(6):478–487.
https://doi.org/10.1080/07315724.2014.950391
Zhao S, Gao Q, Rong C, et al. Immunomodulatory effects of edible and medicinal mushrooms. Journal of Fungi. 2020;6(4):269.
https://doi.org/10.3390/jof6040269
Zhao Q, Jiang Y, Zhao Q, et al. Benefits of edible mushroom polysaccharides for health and gut microbiota. Frontiers in Nutrition. 2023;10:1213010.
https://doi.org/10.3389/fnut.2023.1213010
Mwangi RW, Macharia JM, Wagara IN, Bence RL. The antioxidant potential of edible and medicinal mushrooms. Biomedicine & Pharmacotherapy. 2022;147:112621.
https://doi.org/10.1016/j.biopha.2022.112621
Hamza A, Ghanekar S, Kumar S. Health-promoting potential and biomaterial applications of edible mushrooms. Food Bioscience. 2023;51:102290.
https://doi.org/10.1016/j.fbio.2022.102290
Assemie A, Abaya G. The effect of edible mushrooms on health and their biochemistry. Int J Microbiol. 2022;2022:8744788.
https://doi.org/10.1155/2022/8744788
El-Ramady H, Abdalla N, Badgar K, et al. Edible mushrooms for sustainable and healthy human food. Sustainability. 2022;14(9):5441.
https://doi.org/10.3390/su14095441
Cha S, Bell L, Shukitt-Hale B, Williams C. Effects of mushrooms on mood and neurocognitive health. Neuroscience & Biobehavioral Reviews. 2024;158:105548.
https://doi.org/10.1016/j.neubiorev.2024.105548
Docherty S, Doughty F, Smith E. Lion’s mane supplementation and cognition. Nutrients. 2023;15(22):4842.
https://doi.org/10.3390/nu15224842
Surendran G, Saye J, Jalil S, et al. Acute effects of Hericium erinaceus extract on cognition. Front Nutr. 2025;12:1405796.
https://doi.org/10.3389/fnut.2025.1405796
Saitsu Y, Nishide A, Kikushima K, et al. Improvement of cognitive functions by Hericium erinaceus. Biomedical Research. 2019;40(4):125–131.
https://doi.org/10.2220/biomedres.40.125
Uffelman C, Harold R, Hodson E, et al. Mushrooms in a Mediterranean-style diet and brain health. Foods. 2024;13(15):2319.
https://doi.org/10.3390/foods13152319
Ba DM, Gao X, Al-Shaar L, et al. Mushroom intake and cognitive performance. British Journal of Nutrition. 2022;128(11):2241–2248.
https://doi.org/10.1017/S0007114521005195
Tsuk S, Lev Y, Rotstein A, et al. Clinical effects of Ophiocordyceps sinensis and Ganoderma lucidum. International Journal of Medicinal Mushrooms. 2017;19(8):667–673.
https://doi.org/10.1615/IntJMedMushrooms.2017021202
Luz D, Pinheiro A, Fontes-Júnior EA, Maia C. Ganoderma lucidum cognitive effects. Medical Research Reviews. 2023;43(4):1504–1536.
https://doi.org/10.1002/med.21957
Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Culinary-medicinal mushrooms for neurodegenerative diseases. Critical Reviews in Biotechnology. 2015;35(3):355–368.
https://doi.org/10.3109/07388551.2014.887649
Ern P, Quan T, Yee F, Yin A. Chaga mushroom therapeutic properties. Mycology. 2023;15(3):144–161.
https://doi.org/10.1080/21501203.2023.2260408
Lu Y, Jia Y, Xue Z, et al. Chaga polysaccharides developments. Polymers. 2021;13(9):1441.
https://doi.org/10.3390/polym13091441
Peng H, Shahidi F. Bioactive properties of chaga mushroom. Journal of Food Bioactives. 2020;9:37–54.
https://doi.org/10.31665/JFB.2020.12245
Fordjour E, Manful C, Javed R, et al. Chaga mushroom: untapped potential. Frontiers in Pharmacology. 2023;14:1273786.
https://doi.org/10.3389/fphar.2023.1273786
Nakajima Y, Sato Y, Konishi T. Antioxidant phenolics in chaga. Chemical & Pharmaceutical Bulletin. 2007;55(8):1222–1226.
https://doi.org/10.1248/cpb.55.1222
Camilleri E, Blundell R, Baral B, et al. Maitake mushroom review. Heliyon. 2024;10(7):e30254.
https://doi.org/10.1016/j.heliyon.2024.e30254
Wu J, Siu KC, Geng P. Bioactive ingredients of Grifola frondosa. Foods. 2021;10(1):95.
https://doi.org/10.3390/foods10010095
He X, Wang X, Fang J, et al. Polysaccharides in Grifola frondosa. International Journal of Biological Macromolecules. 2017;101:910–921.
https://doi.org/10.1016/j.ijbiomac.2017.03.177
Boh B, Berovič M. Medicinal properties of maitake mushroom. Int J Med Mushrooms. 2007;9(2):89–108.
https://doi.org/10.1615/IntJMedMushr.v9.i2.10
Bai Y, Chen L, Chen Y, et al. Maitake polysaccharide and Alzheimer’s disease pathology. RSC Advances. 2019;9:37127–37135.
https://doi.org/10.1039/C9RA08245J
Mayell M. Maitake extracts and their therapeutic potential. Alternative Medicine Review. 2001;6(1):48–60. https://pubmed.ncbi.nlm.nih.gov/11207456/
Chapters
00:00 Intro
00:23 Mushroom Overview
01:03 Benefits of Mushrooms
01:40 Choosing Mushroom Brands
01:57 Nutritional Benefits of Mushrooms
03:31 Health Claims and Effects
05:07 Specific Mushroom Types
06:04 Research and Studies About Mushrooms
08:01 Conclusion and Takeaways
09:30 Outro
Sample Recipes
These recipes are designed to make incorporating functional mushrooms into your daily routine as simple as enjoyable as possible.
Mushroom Morning Coffee
Best with: Lion's Mane, Reishi, or Cordyceps powder
Brew your coffee or tea as usual. Add 1/2 to 1 teaspoon of your chosen mushroom powder (approximately 500-1,000 mg) along with a splash of your preferred milk or creamer. Sweeten to taste.
Oyster Mushroom and Egg Scramble
Serving size: 100-150g fresh oyster mushroom
Sauté oyster mushrooms in olive oil with a pinch of salt until tender and slightly caramelized, about 5-6 minutes. Add two to three beaten eggs and scramble together. Finish with fresh herbs, black pepper, and a squeeze of lemon.
Maitake and Sweet Potato Soup
Serving size: 50-100g fresh maitake per portion
Sauté diced onion and garlic in olive oil until soft. Add cubed sweet potatoes, maitake mushrooms, vegetable broth, and a pinch of turmeric and black pepper. Simmer for 20 minutes until the sweet potato is tender. Blend partially for a creamy texture or leave chunky.