In this episode, I sit down with Carly Alarcon, founder of YVB, to talk about her journey into adaptogens, medicinal mushrooms, nutraceuticals, and what it really means to build supplements with integrity.
​
We cover how adaptogens work, what to look for (and avoid) on supplement labels, and the sustainable practices behind the YVB brand. We also get into Carly’s origin story and how she built YVB and why sustainability and efficacy go hand in hand.
​
If you’ve ever wondered whether your mushroom supplements are actually doing anything, this one is for you.
Follow us
​
Medical Providers Join my Clinician Education Platform
​
​
Carly Alarcon of YVB
​
​
References
​
Hseu YC, Chen SC, Chen HC, Liao JW, Yang HL. Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo. Food and Chemical Toxicology. 2008;46(8):2680–2688.
https://doi.org/10.1016/j.fct.2008.04.036
​
Chang TT, Chou WN. Antrodia cinnamomea: traditional use and its pharmacological activity. Journal of Ethnopharmacology. 2004;91(2–3):201–208.
https://doi.org/10.1016/j.jep.2003.12.011
​
Yang HL, Kuo YH, Tsai CT, Huang YT, Chen SC, Chang HW, Lin E, Lin WH, Hseu YC. Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food and Chemical Toxicology. 2011;49(1):290–298.
https://doi.org/10.1016/j.fct.2010.10.031
​
Liu DZ, Liang HJ, Chen CH, Su CH, Lee TH, Huang CT, Hou WC, Lin SY, Zhong WB, Lin PJ, Hung LF. Hepatoprotective effects of Antrodia cinnamomea. Journal of Ethnopharmacology. 2007;112(3):537–542.
https://doi.org/10.1016/j.jep.2007.03.033
​
Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J. Efficacy of Agaricus blazei Murill in patients with gynecological cancer treated with chemotherapy. Evidence-Based Complementary and Alternative Medicine. 2009;6(4):489–495.
https://doi.org/10.1093/ecam/nem161
​
Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. Effects of Agaricus blazei extract on insulin resistance in patients with type 2 diabetes: a randomized clinical trial. Journal of Alternative and Complementary Medicine. 2007;13(1):97–102.
https://doi.org/10.1089/acm.2006.6015
​
Firenzuoli F, Gori L, Lombardo G. The medicinal mushroom Agaricus blazei Murill: review of literature and pharmaco-toxicological problems. Evidence-Based Complementary and Alternative Medicine. 2008;5(1):3–15.
https://doi.org/10.1093/ecam/nem007
​
Mitomi T, Tsuchiya S, Iijima N, et al. Randomized controlled study of chemotherapy plus PSK versus chemotherapy alone for colorectal cancer. Diseases of the Colon & Rectum. 1992;35(2):123–130.
https://doi.org/10.1007/BF02050307
​
Torkelson CJ, Sweet E, Martzen MR, et al. Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncology. 2012.
https://doi.org/10.5402/2012/251632
​
Stamets P, Holliday J, Cleaver M. Turkey tail mushrooms (Trametes versicolor) and NK cell activity in breast cancer patients. Global Advances in Health and Medicine. 2012;1(5):32–43.
https://doi.org/10.7453/gahmj.2012.1.5.009
​
Pallav K, Dowd SE, Villafuerte J, et al. Effects of polysaccharopeptide from Trametes versicolor on human gut microbiota. Gut Microbes. 2014;5(4):458–467.
https://doi.org/10.4161/gmic.29558
​
Bao PP, Shu XO, Gao YT, et al. Use of mushroom-derived polysaccharide-K (PSK) and breast cancer survival outcomes. American Journal of Clinical Nutrition. 2012;96(2):275–282.
https://doi.org/10.3945/ajcn.111.030114
​
Konno S. A possible hypoglycaemic effect of maitake mushroom on type 2 diabetic patients. Diabetic Medicine. 2001;18(12):1010.
https://doi.org/10.1046/j.1464-5491.2001.00653.x
​
Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom D-fraction induces ovulation in patients with polycystic ovary syndrome. Journal of Alternative and Complementary Medicine. 2010;16(12):1295–1299.
https://doi.org/10.1089/acm.2009.0547
​
Deng G, Lin H, Seidman A, et al. A phase I/II trial of a polysaccharide extract from Grifola frondosa in breast cancer patients. Journal of Cancer Research and Clinical Oncology. 2009;135(9):1215–1221.
https://doi.org/10.1007/s00432-009-0562-z
​
Dai X, Stanilka JM, Rowe CA, et al. Consuming Lentinula edodes (shiitake) mushrooms daily improves human immunity. Journal of the American College of Nutrition. 2015;34(6):478–487.
https://doi.org/10.1080/07315724.2014.950391
​
Shimada Y, Morita T, Sugiyama K. Eritadenine inhibits hypercholesterolemia in rats. Journal of Nutritional Science and Vitaminology. 2003;49(6):423–428.
https://doi.org/10.3177/jnsv.49.423
​
Cheah IK, Halliwell B. Ergothioneine; antioxidant potential and role in longevity. Biochimica et Biophysica Acta. 2012;1822(5):784–793.
https://doi.org/10.1016/j.bbadis.2011.09.017
​
Chen S, Li Z, Krochmal R, et al. Effect of Cs-4 (Cordyceps sinensis) on exercise performance and recovery in older adults. Journal of Alternative and Complementary Medicine. 2010;16(5):585–590.
https://doi.org/10.1089/acm.2009.0226
​
Hirsch KR, Smith-Ryan AE, Roelofs EJ, et al. Cordyceps militaris improves tolerance to high-intensity exercise. Journal of Dietary Supplements. 2017;14(1):42–53.
https://doi.org/10.1080/19390211.2016.1203386
​
Huang YL, Leu SF, Liu BC, et al. Extracts from Cordyceps sinensis potentiate testosterone biosynthesis. Life Sciences. 2004;75(9):1051–1062.
https://doi.org/10.1016/j.lfs.2004.01.026
​
Géry A, Dubreuil L, Gautier R, et al. Chaga mushroom extract inhibits oxidative DNA damage. Nutrients. 2018;10(11):1575.
https://doi.org/10.3390/nu10111575
​
Xu X, Yan H, Chen J, et al. Polysaccharides from Inonotus obliquus reduce blood glucose. International Journal of Biological Macromolecules. 2010;47(4):510–514.
https://doi.org/10.1016/j.ijbiomac.2010.07.010
​
Fulda S. Betulinic acid for cancer treatment and prevention. International Journal of Molecular Sciences. 2008;9(6):1096–1107.
https://doi.org/10.3390/ijms9061096
​
Gao Y, Zhou S, Chen G, et al. Effects of Ganopoly (Ganoderma lucidum polysaccharides) on immune function in advanced-stage cancer patients. Immunological Investigations. 2003;32(3):201–215.
https://doi.org/10.1081/IMM-120022975
​
Zhao H, Zhang Q, Zhao L, et al. Spore powder of Ganoderma lucidum improves cancer-related fatigue in breast cancer patients. Evidence-Based Complementary and Alternative Medicine. 2012.
https://doi.org/10.1155/2012/809614
​
Cui XY, Cui SY, Zhang J, et al. Extract of Ganoderma lucidum prolongs sleep time in rats. Journal of Ethnopharmacology. 2012;139(3):796–800.
https://doi.org/10.1016/j.jep.2011.12.020
​
Wang CZ, Calway T, Yuan CS. Reishi mushroom (Ganoderma lucidum) and NF-κB pathway inhibition. Frontiers in Pharmacology. 2021;12:691706.
https://doi.org/10.3389/fphar.2021.691706
​
Mori K, Inatomi S, Ouchi K, et al. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment. Phytotherapy Research. 2009;23(3):367–372.
https://doi.org/10.1002/ptr.2634
​
Tzeng TT, Chen CC, Chen CH, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease. Journal of Biomedical Science. 2018;25(1):77.
https://doi.org/10.1186/s12929-018-0471-7
​
Docherty S, Doughty F, Smith E. Neurotrophic properties of the Lion’s Mane medicinal mushroom. International Journal of Molecular Sciences. 2023;24(4):3284.
https://doi.org/10.3390/ijms24043284
​
Lowenthal RM, Tormey CA, et al. Medicinal mushrooms in cancer therapy: clinical evidence and mechanisms. Biomedicine & Pharmacotherapy. 2023;161:114424.
https://doi.org/10.1016/j.biopha.2023.114424
​
Narayanan S, Shanmugam VK, et al. Medicinal mushrooms in oncology: current perspectives and future directions. Current Oncology Reports. 2023;25(6):569–587.
https://doi.org/10.1007/s11912-023-01377-8
​
Wasser SP. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Applied Microbiology and Biotechnology. 2002;60(3):258–274.
https://doi.org/10.1007/s00253-002-1076-7
​
Lu H, Kyo E, Uesaka T, et al. PSK as an immunomodulator in cancer therapy. Clinical Cancer Research. 2011;17(1):67–76.
https://doi.org/10.1158/1078-0432.CCR-10-1965
​
Dou H, Chen J, Wang Y, et al. Medicinal mushrooms and cancer therapy: translational perspectives. Progress in Molecular Biology and Translational Science. 2019;163:361–381.
https://doi.org/10.1016/bs.pmbts.2019.02.003
​
Pilkington K, Jeitler M, et al. Medicinal mushrooms for cancer care. Cochrane Database of Systematic Reviews. 2022;CD012053.
https://doi.org/10.1002/14651858.CD012053.pub2
​
Sakamoto J, Morita S, et al. Efficacy of polysaccharide-K (PSK) in colorectal cancer: meta-analysis of randomized trials. Cancer Immunology, Immunotherapy. 2006;55(4):404–411.
https://doi.org/10.1007/s00262-005-0035-z
​
Ma Y, Zhang Y, Li X, et al. Immunomodulatory and anticancer activities of medicinal mushroom polysaccharides. Oncotarget. 2017;8(51):89108–89118.
https://doi.org/10.18632/oncotarget.20944
​
Fritz H, Kennedy DA, Ishii M, et al. Medicinal mushrooms for cancer: systematic review and meta-analysis. Integrative Cancer Therapies. 2015;14(3):201–211.
https://doi.org/10.1177/1534735415577591
​
Jeitler M, Michalsen A, et al. Medicinal mushrooms in cancer therapy: clinical evidence and mechanisms. Frontiers in Pharmacology. 2020;11:580656.
https://doi.org/10.3389/fphar.2020.580656
​
Turkey tail mushroom (Trametes versicolor) is widely studied in integrative oncology for its immune-modulating properties. Compounds in the mushroom–especially polysaccharide-K (PSK) and polysaccharopeptide (PSP)–do not directly kill cancer cells in humans, but they can enhance the body’s immune response to tumors. These compounds act as biological response modifiers that stimulate immune cells such as natural killer (NK) cells, CD8+ T cells, and dendritic cells, and increase cytokine signaling involved in antitumor immunity. Experimental studies also show that turkey tail extracts can inhibit cancer cell growth and induce apoptosis in laboratory models, although these effects occur at concentrations that may not reflect clinical dosing.
​
Clinically, PSK has been used in Japan as an adjunct to chemotherapy, and randomized trials and meta-analyses suggest modest improvements in survival outcomes for some cancers, including colorectal and gastric cancer, when combined with conventional therapy. However, the certainty of evidence remains low to moderate due to small study sizes and older chemotherapy protocols, so turkey tail is considered a complementary–not curative, approach in cancer care.
Chapters
00:00 Intro
00:18 Guest Introduction: Carly Alarcon
01:22 Carly's Personal Health Journey
03:33 Founding of YVB
05:45 The Role of Mushrooms and Adaptogens
06:52 Meditation and Stress Management
09:22 Business Evolution and Product Offerings
14:53 Environmental and Ethical Practices
19:49 Family Business Dynamics
22:38 Maintaining Wellness as an Entrepreneur
27:11 Product Showcase and Recommendations
36:36 Supplement Industry Insights
42:44 Future Plans for YVB
44:13 Conclusion
44:34 Outro
